Synthetic Approaches to Heterocyclic Ligands for Gd-Based MRI Contrast Agents

Synthetic approaches to heterocyclic ligands for Gd-based MRI contrast agents.

Magnetic Resonance Imaging (MRI) methods are currently used in the clinic for the non invasive detection and characterization of a wide variety of pathologies. Increases in the diagnostic efficiency of MRI have been helped by both the design of dedicated MR sequences revealing specific aspects of the pathology and by the development of more sensitive and selective Contrast Agents (CAs), capable...

Development of Gd@C60 Based MRI Contrast Enhancing Agents

Multimeric Gd-based Contrast Agents for high field MR-imaging

Introduction. MR imaging is increasingly moving to higher fields as the majority of MRI scanners used in clinics work at 3 T. Imaging at high fields brings greater signal-to-noise ratio (SNR) and its concomitant benefits of higher spatial resolution and/or reduced acquisition times. Currently employed Gd-based contrast agents are small, fast tumbling molecules with low relaxivity that decreases...

Contrast agents for hepatic MRI

Liver specific contrast media (LSCM) can be subdivided according to different modalities of hepatic distribution: exclusive distribution to the hepatocellular compartment can be obtained using CM which accumulate within the hepatocytes after slow infusion; other CM demonstrate combined perfusion and hepatocyte-selective properties, with an initial distribution to the vascular-interstitial compa...

Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents

Biocompatible poly-[N-(2-hydroxyethyl)-d,l-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C(16)) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C(16)-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesize...